VitalzymSEB is no longer available. We have chosen to replace it with Serracor from the company that originated the SEB formulas.

SEBkinase-CV ~ The Original Formula ~ AST Enzymes is a part of SEBGroup USA, Manufacturing Enzymes Since 1957.

Enteric Coated Nattokinase and Serrapeptase
Formulated to maintain fibrin metabolism and support
a healthy cardiovascular system*

SEBkinase®,NattoSEB®, and
Peptizyme SP® Serracor-NK
are registered trademarks of
Specialty Enzymes and Biochemicals Co.

The Largest Manufacturer of
Serrapeptase in the World

Serracor-NK Promotes:
• Heart and Circulatory Health*
• Fibrinolytic Activity and Normal Blood Viscosity*
• Healthy Blood Pressure*
• Blood Cleansing*
• C-Reactive Protein Reduction*
• Healthy Response to Inflammation*
• Normal Immune Function*

300 Capsules: $164.99 Now $124.99

(Current enzyme users - Please call for a special introductory price
if you have been using a different brand of enzymes)

Does your current systemic enzyme formula contain enteric coated nattokinase and serrapeptase?

Probably not. Serracor-NK™ contains the original Neprinol® formula containing SEBkinase® with enteric coated nattokinase and serrapeptase. We are the original manufacturer of this formula that has been imitated by many others. For more information read about Serracor-NK setting the record straight.

Why is enteric coated Nattokinase and Serrapeptase important?

Most nattokinase and serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their fibrinolytic activity and effectiveness in the acidic environment of the stomach. The enteric coating of our SEBkinase blend allows these sensitive enzymes to survive the acidic conditions of the stomach, thus allowing them to pass into the circulatory system maintaining high activity levels.

How do Fibrinolytic Units (FU's) relate to enteric coating?

Enzyme activity measured in fibrinolytic units do not mean anything if the enzymes are destroyed and/or denatured in the high acidic conditions of the stomach, Period! Under these conditions, our laboratory tests have consistently shown that serrapeptase and nattokinase lose significant activity when exposed to low pH (such as those in the stomach). In contrast, our enteric coated nattokinase and serrapeptase (the original SEBkinase formula) perform at greater activity levels in the same low pH conditions. The pH resistant enteric coating will disintegrate after it enters the alkaline environment of the intestines. If your enzyme formula is not enterically coated, you may be wasting your money.

Serracor-NK for Circulatory Support

Did you know cardiovascular disease is the biggest killer in America? Arterial plaque build-up, excessive fibrin levels, as well as metabolic waste matter, can all slow-down normal blood circulation. A healthy vascular system must supply oxygenated blood to vital organs including the heart and brain.

Serracor-NK is a fibrinolytic enzyme blend that exhibits natural anti-inflammatory properties, helps normalize fibrin levels in the circulatory system, reduces C-reactive protein and normalizes both blood viscosity and platelet stickiness.*

SEBkinase-CV brings together two enteric coated, fibrinolytic proteases: Peptizyme SP® (Serrapeptase) and NattoSEB® (our Nattokinase is Vitamin K Free, since it assists in blood coagulation). Serracor-NK further supports the activity of SEBkinase-CV with a complete array of proteolytic enzymes, amylase, lipase, CoQ10, herbs and minerals. The net result is a comprehensive systemic enzyme blend designed to support maximum cardiovascular health.*

Serracor-NK also promotes healthy levels of C-reactive protein, an inflammation marker and serious risk factor for cardiovascular disease.* In addition, the entire systemic enzyme blend is manufactured in a ISO 9001:2000 and GMP certified facilities using our Bioactive Protein Peptide System™ (BPPS)

Enhanced BPPS Delivery Technology

  • Provides Enhanced Absorption
  • Greater Enzyme Stability
  • Increases Bio-availability

Fibrin performs an important function in the body, including clotting and wound healing. However, excessive fibrin can impede normal blood flow, which may lead to increased blood viscosity, swelling, edema, pain, inflammation and more serious cardiovascular events. The proteases in Serracor-NK reduce fibrin levels and improve viscosity and over all blood circulation.*

Nattokinase Research - Fibrinoyltic Activity

In vitro and in vivo studies have consistently demonstrated the potent fibrinolytic effect of Nattokinase.1 Research with nattokinase demonstrates that it may help avoid or reduce the likelihood of deep vein thrombosis, cardiac infarction, pulmonary emboli and stroke. It appears to accomplish this via its finbrinolytic, anti-inflammatory and modulating effect on blood pressure. Studies on hypertension demonstrate an average drop of 10.9% in Systolic Blood Pressure and a 9.7 percent drop in Diastolic Blood Pressure.2,3,4

A study conducted with natto on 12 healthy adults (6 men and 6 women, between the ages of 21 and 55) sought to demonstrate fibrinolytic activity. The volunteers were given 200 grams of natto (the food) before breakfast, then their fibrinolytic activity was tested over time. The results indicate natto generates an increased ability to dissolve blood clots. As a control, researchers later fed the same amount of boiled soybeans to the same volunteers and tracked their fibrinolytic activity. The tests showed no significant change.5

The accumulation of fibrin in blood vessels significantly increases the likelihood of thrombosis formation resulting in a cardiovascular event. For thrombolytic therapy, microbial fibrinolytic enzymes are now much more accepted. The physiochemical properties of this enzyme is becoming well characterized and its effectiveness in thrombolysis in vivo has been further identified.6,7

Nattokinase and Blood Clots

Blood clots (thrombi) form when strands of fibrin accumulate in the circulatory system. These clots can cause blockage of blood flow. If blood flow is blocked, the oxygen supply to that tissue is cut off and it eventually dies. In the heart, this can result in myocardial infarction (heart attack). In the brain, it can result in strokes or mini-strokes. Deep vein thrombosis can result in pulmonary emboli. All these events can be life-threatening. An in vitro study not only demonstrated the powerful fibrinolytic activity of nattokinase, but also showed the significant reduction in the aggregation of red blood cells and overall lowered whole blood viscosity. The net results are vascular conditions that are less likely to produce blood clots. The authors suggest that nattokinase possesses very real potential as a therapeutic agent in cardiovascular health.8

The process of forming a clot is complex and involves several enzymes. However, the body mainly produces one central enzyme for dissolving a clot, plasmin. It happens that the properties of nattokinase are very similar to plasmin. Nattokinase is particularly effective because it enhances the body's natural ability to fight blood clots in several different ways. It dissolves fibrin directly and appears to enhance the body's natural production of both plasmin and other clot-dissolving enzymes like urokinase. An in vivo study was undertaken to demonstrate the thrombolytic activity of nattokinase, plasmin and elastase on an induced clot in the common carotid artery of laboratory rats. The results indicate that the thrombolytic activity of nattokinase is stronger than that of plasmin or elastase in vivo in this model.9

A fascinating study was conducted to measure the effect of nattokinase in the prevention of deep vein thrombosis and superficial vein thrombosis on extended flights of 7-8 hours on high-risk individuals. The nattokinase group had no thromboses. The placebo group had 5 deep vein thromboses and 2 superficial vein thromboses or 7.6% of 94 individuals. After the flight, the degree of edema was increased by 12% in the placebo group and decreased by 15% in the nattokinase group. The authors concluded that nattokinase was effective in reducing thrombotic events and in controlling edema in high-risk subjects on long flights.10

About AST Enzymes

Advanced Supplemental Therapies, a leading enzyme manufacturer, provides healthcare professionals and consumers with pharmaceutical-grade enzyme supplements for cardiovascular, anti-inflammatory, joint, digestive and colon health.

Our enzyme supplements, unlike those of most nutraceutical companies, are manufactured and formulated in-house - assuring you receive the highest quality, activity, purity and safety.

AST Enzymes is a member of SEB Group, a family of companies with more than 50 years of enzyme manufacturing and formulating experience.

We use only non-genetically modified, natural ingredients, tested by our industry-leading team of scientists and experts.

AST Enzyme blends are formulated by our expert enzymologist Vic Rathi, who has more than 35 years of experience in enzyme research, technical innovation and development of hundreds of efficacious formulas for the nutraceutical industry.

The supplements are manufactured in ISO 9001:2000 and GMP-certified facilities using our Bioactive Protein Peptide System (BPPS), a manufacturing process that improves enzyme absorption, stability and bioavailability -- allowing us to bring you the highest quality, most effective systemic enzymes.

Serracor-NK contains the following ingredients:

SEBkinase is a systemic enzyme blend of two enteric coated, fibrinolytic proteases: Peptizyme SP (Serrapeptase) & NattoSEB (our Nattokinase contains NO Vitamin K).

NATTOKINASE (NattoSEB) is derived from natto, a traditional Japanese food made from fermented soybeans. Natto has been known for centuries for its positive medicinal properties, particularly for cardiovascular disorders. To make natt?, soybeans are fermented with the beneficial bacteria Bacillus natto (sometimes listed as Bacillus subtilis natto). During fermentation, the Bacilli produce enzymatic proteases, the most important of which is nattokinase. Like other proteases, nattokinase has potent anti-inflammatory activity, as well as several other beneficial properties, including fibrinolytic activity. A researcher, Hiroyuki Sumi, identified the active enzyme in natto and demonstrated its ability to dissolve vascular blood clots. He called this enzyme "nattokinase"-meaning "enzyme in natto."

SERRAPEPTASE (Peptizyme SP) is an enzyme derived from a species of bacteria originally found in the intestine of silkworms. The bacteria, Serratia mercesans produces the enzyme that enables the silkworm to dissolve its silken cocoon and emerge after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation. Numerous research and clinical studies demonstrate serrapeptase's formidable anti-inflammatory, proteolytic (protein dissolving) and fibrinolytic (fibrin dissolving) properties. They also show that scar tissue is greatly reduced and proteins involved in the inflammatory process are effectively digested. Serrapeptase is a protease that has been used in Japan and Europe for over four decades for its anti-inflammatory activity.

BROMELAIN is a collective name for the proteolytic (protein-digesting) enzymes found in the pineapple plant (Ananas comosus), and is known for its digestive as well its anti-inflammatory properties. Because of its activity across a wide pH range, bromelain is a good substitute for pepsin and trypsin for both digestive and systemic support.*

PAPAIN is a widely used enzyme obtained from the latex of the fruit of the Papaya tree (Carica papaya). Papain has been used for centuries as an effective digestive aid.

LIPASE catalyzes the break-down of fats into essential fatty acids that are needed for healthy tissues and cells.*

PROTEASES are enzymes that hydrolyze (break-down) proteins like meat, casein, gelatin, soy, fish and other plant and animal proteins to smaller chains of polypeptides (small proteins) and amino acids for easier uptake throughout the body.

RUTIN is a bioflavonoid that strengthens and tones arteries and veins and provides antioxidant support against free-radicals and inflammation.*

AMLA, or Indian gooseberry (Emblica officinalis), is a natural and efficacious antioxidant. It is one of the richest sources of absorbable vitamin C available.

COENZYME Q10 is an essential enzyme and cofactor in metabolism that is naturally made and stored in the liver, kidneys, and heart. It is a vital part of energy production and overall cell health.*

MAGNESIUM is an essential mineral used as a cofactor by over 350 enzymes in the body. Magnesium is critical part of cardiovascular and nerve physiology. It helps relax arteries and assists in proper nerve impulse function.*


1. Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinases
Acta Haematol 1990; 84:139-143. Hiroyuki Sumia, Hiroki Hamadab, Koichiro Nakanishic, Hajime Hiratanic
aDepartment of Physiology, Miyazaki Medical College, Miyazaki, Japan;
bDepartment of Biochemistry, Oklahoma State University, Okla., USA;
cBiochemistry Research Laboratories, JCR Pharmaceuticals, Kobe, Japan

2. Prevent Heart Attack and Stroke with Potent Enzyme that Dissolves Deadly Blood Clots in Hours. Health Sciences Institute, March 2002.

3. Effect of Natto Diet on Blood Pressure. JTTAS, 1995. Maruyama M, Sumi H..

4. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research 31, 1583-1588 (2008) Ji Young Kim 1,2, Si Nae Gum2,3, Jean Kyung Paik2,4,5,

5. Purification and Characterization of a Strong Fibrinolytic Enzyme (Nattokinase) in the Vegetable Cheese Natto, a Popular Soybean Fermented Food in Japan. Biochemical and Biophysical Research Communications, Vol. 197, Issue 3, 30 December 1993, pp. 1340-1347 Fujita M., Nomura K., Hong K., Ito Y., Asada A. and Nishimuro S. Jcr Pharmaceut Co Ltd, Biotechnol Res Labs, 3 2 61 Takatsukadai, Nishi Ku, Kobe 65122, Japan

6. Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo. Applied Microbiology and Biotechnology Vol. 69, No. 2, November, 2005, pp- 126-132

7. Nattokinase for prevention of thrombosis. Am J Health Syst Pharm, 63(12): 1121-3 2006
Tai MW , Sweet BV

8. Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity. Clin Hemorheol Microcirc 2006; 35(1-2):139-42. Pais E, Alexy T, Holsworth RE, Meiselman HJ

9. Thrombolytic Effect of Nattokinase on a Chemically Induced Thrombosis Model in Rat. Biological & Pharmaceutical Bulletin Vol.18 , No.10 (1995) pp.1387-1391 Mitsugu Fujita1, Kyongsu Hong1, Yae Ito1, Rie Fujii2, Kimio KARIYA2 and Satoshi NISHIMURO3

10. Prevention of Venous Thrombosis in Long-Haul Flights with Flite Tabs: The LONFLIT-FLITE Randomized, Controlled Trial Angiology, Vol. 54, No. 5, 531-539 (2003) M.R. Cesarone, et al.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any diseases.

All material on this website is for informational purposes only. Nothing contained on this website is intended to be used as a medical diagnosis or treatment. It should not be used in place of the advice of your physician or qualified healthcare provider.

Neprinol® is a registered trademark of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other product from Specialty Enzymes & Biochemicals Co.

All information on this website is compiled is strictly for educational purposes and Naturally Better not responsible for this information. The FDA has not evaluated these statements. Products and/or statements are not intended to diagnose, treat, cure or prevent disease. Consult with a healthcare professional.