www.naturallybetter.com - www.all-new-you.com
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Introducing............. Advanced Bone ProtectionTM
contains MBP, an active protein complex from the whey fraction of milk.
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What Is
Advanced Bone ProtectionTM ?
Milk in general (and bovine
milk in particular) arguably contains more growth factors than any other
single food source. Growth factors are specific proteins which act as intracellular
signaling molecules. Scientists in Japan have isolated a fraction from
whey protein which they have determined to have positive metabolic effects
on bone health. It is called Milk Basic Protein, or MBP®, and it is
the active ingredient in Advanced Bone Protection from AORTM.
How Does Advanced Bone ProtectionTM
Work ?
Stated very briefly, MBP
stimulates the activity and proliferation of osteoblasts (bone-building
cells) while simultaneously suppressing the activity and proliferation
of osteoclasts (cells responsible for the resorption - or breakdown - of
bone). MBP is particularly effective at supporting the production of collagen
as well as the retention of calcium (see below).
At first glance, the mechanism of action through which MBP exerts its effects seems remarkably similar to that of its bone-enhancing nutrient predecessors such as calcium, vitamin D and strontium. For example, MBP assists in the absorption and retention of calcium, just as vitamin D does. Unlike vitamin D, however, MBP does so via the inhibition of cystein protease due to the presence of the protein strain known as cystatin C, which is part of the structure of MBP itself. Cystatin C also inhibits the release of calcium from bones stimulated by thrombin, interleukin-1 and prostaglandin E2. The essential nature of this function cannot be understated, as calcium can metaphorically be referred to as the mortar for the infrastructure that is collagen - together contributing to form the complex that is bone.
Cystein protease also digests collagen in the bone matrix, further testimony to the benefit of its inhibitory effect from the cystatin C contained in MBP. MBP cultivates both the proliferation and activity of the bone-building osteoblasts while conversely bridling the same proliferation and activity among the osteoclasts responsible for the resorption (breakdown) of older bone tissue. Even more revealing is the extent of MBP's inhibition of osteoclasts, suppressing the activity of even the most isolated osteoclast cells. The association between the osteoblast/osteoclast relationship and collagen lies in the ability of osteoblasts to produce collagen, and it is here where MBP comes into its own. The ability to specifically manipulate osteoblasts into producing more collagen in a manner that is more pronounced than that of its osteo-nutrient predecessors is an additional factor that makes MBP unique. Furthermore, MBP also increases serum concentrations of osteocalcin (BGP, also called Gla protein), which is the major non-collagenous protein in bone.
Science In Action: What The
Studies Say
As with all promising nutraceutical
innovations, early in-vitro research revealed encouraging indications of
what would later become identified as MBP. Indeed, such indications at
the in-vitro level need to be encouraging in order to secure further, in-vivo
studies. This preliminary research identified whey protein as having an
exemplary influence on the relationship between osteoblasts and osteoclasts.
It was discovered that in addition to fortifying osteoblasts, whey protein
was also shown to suppress osteoclast-mediated bone resorption and osteoclast
cell formation. This began a lengthy scientific process to isolate the
fraction of whey protein that scientists believed was responsible for these
bone-reinforcing effects. MBP was the eventual result of that process.
The recent scientific isolation and practical procurement of MBP has lead to numerous studies with excitingly impressive results. The first study among humans involved thirty-three healthy women who were randomly assigned to treatment with either a placebo or MBP (40 mg per day) for six months. The bone mineral density (BMD) of the left heel bone of each subject was measured at the beginning of the study and at the end. Serum and urine indices of bone metabolism were measured at the base line, threemonth intervals, and again at the end of the study. When standard BMD testing was conducted at the end of the study, the women in the MBP group gained approximately 70% more bone mineral density than the control group. Furthermore, urinary markers of bone loss - in this case, cross-linked type- I collagen/creatinine and deoxypyridinoline/creatinine, were 'significantly decreased' in the MBP group.
A study among healthy adult men was similarly impressive, as well as another study among healthy adult women in 2002. This particular double-blind, placebo-controlled trial measured radial bone mineral density, and once again the mean BMD value of the MBP group was 'significantly higher' than that of the placebo group.
A Summary of the Results
of MBP Studies:
• In a study among healthy
menopausal women, the MBP group reported a bone mineral density (BMD) increase
of 1.21% while the placebo group recorded a 0.66% BMD decrease.
• In another study among
healthy adult women, the MBP group gained approximately 70% more bone mineral
density than the control group.
• MBP reduced the number
of pits on the bone surface caused by bone resorption by approximately
85% in an in-vitro study.
• In yet another study among
healthy adult females, the MBP group displayed a 3% increase in the BMD
of the radius (a forearm bone near the wrist) compared to a 1.3% BMD decrease
in the placebo group.
Finally, the MBP in Advanced
Bone ProtectionTM from AOR comes in small, convenient capsules that can
be taken with or without food and have no interactions with calcium or
any other nutrients
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SUPPLEMENT FACTS:
Serving Size: 1 Capsule
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MBP† (A specific basic protein
fraction derived from milk) 40mg
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† MBPTM is owned by Snow
Brand Milk Products Co., Ltd. in Canada
Other ingredients: Microcrystalline
cellulose. Capsule: hypromellose, sorbitol, silicon dioxide, water.
AOR guarantees that no ingredients
not listed on the label have been added to the product. Contains no wheat,
gluten, corn, nuts, soy, eggs, fish or shellfish.
Suggested Use
Take one capsule daily with/without
food or as directed by a qualified health care practitioner.
Main Applications
* Supports skeletal health
Source
Bovine Milk.
Pregnancy / Nursing
No studies, best to avoid.
Cautions
Advanced Bone ProtectionTM
is not recommended for people with milk allergies.
*These statements have not
been evaluated by the Food and Drug Administration. This product is not
intended to diagnose, treat, cure, or prevent any disease.
The information and product descriptions appearing on this website are
for information purposes
only, and are not intended to provide medical advice to individuals. Consult
with your physician if
you have any health concerns, and before initiating any new diet, exercise,
supplement, or other
lifestyle changes.
To order call 888-660-8831 or order online at www.naturallybetter.net
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